Serotonin Toxicity

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The use of Garcinia cambogia , a popular weight-loss supplement, may pose health risks to people who are taking certain antidepressants, a recent case report suggests.

This review will discuss serotonin syndrome. A discussion of selective serotonin reuptake inhibitor (SSRI) intoxication and a general approach to management of the poisoned patient are found elsewhere. (See "Selective serotonin reuptake inhibitor poisoning" and "General approach to drug poisoning in adults" and "Initial management of the critically ill adult with an unknown overdose" .)

Venlafaxine , sold under the brand names Effexor among others, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. [3] [4] [5] This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain. First introduced by Wyeth in 1993, now marketed by Pfizer , it is licensed for the treatment of major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia . [6] [7]

ATN follows a well-defined three-part sequence of initiation, maintenance, and recovery (see Pathophysiology). The initiation phase is characterized by an acute decrease in glomerular filtration rate (GFR) to very low levels, with a sudden increase in serum creatinine and blood urea nitrogen (BUN) concentrations.